Imwe nyika kurwa kumwe
─International Kubatana Kuvaka Nharaunda Yepasi Pose yeChiitiko Zvakajairika Kupindura KuChid-19 Zvinonetsa 19
NOLOL CORONOSVAVIRUS SKOURE PASI PASI PASI PASI PASI PASI PASI PASI PASI PASI PASI PASI-19 PANEMC CRISIS. Novel Coronavirus haana miganhu, hapana nyika ichasiyiwa kubva kuhondo iyi kurwisa Chand-19. Mukupindura uripo pasi rose
Nyika yedu yasangana nemhedzisiro isingaenzaniswi yeiyo novel coronavirus chirwere 2019 (chovid-19) dengic. Kusvika parizvino, hapana mushonga unoshanda unowanikwa kurapwa kwechirwere ichi. Nekudaro, miedzo yakawanda yekuongorora yakagadziriswa yekuonekwa kweCavid-19. Iyi miedzo yakavakirwa pamigwagwa yemanyorerwo kana sosi yekuona iyo novel coronavirus chaiyo nucid kana antibody biomarkers. Sekureva kwechiitiko, kutanga kuongororwa kwehurumende kwehutachiona kwehutachiona kwakakosha mukuongorora kupararira kwehutachiona uye kuve nazvo, asi muedzo wakakwana wekushandisa zvakasikwa zvisati zvasvika. Isu tinofanirwa kuziva kuti ndedzipi bvunzo dzaigona kushandiswa pakuongorora, kuongororwa, uye kuongorora kweiyo shanduko-19 utachiona, uye chii chavasingakwanisi. Zvakakosha kwazvo kuti ushandise zviri nani izvi zvishandiso zvesainzi uye kubatsira kuziva uye kudzora kubuda kwehurwere hunopararira uye hwakakomba chirwere.
Chinangwa chekuonekwa kweNovel Coronavirus ndechekuti one kana munhu ane hutachiona hwechiratidzo kana chingotakura hutachiona hunokwanisa kutapurira pachena, kupa ruzivo rwakakosha kutungamira kuita sarudzo yekurapwa kwekiriniki. Zvidzidzo zvapfuura zvakaratidza kuti 70% yesarudzo dzekiriniki dzinoenderana nemhedzisiro yekuyedza. Kana nzira dzakasiyana dzekuona dzinoshandiswa, izvo zvinodiwa pakuongororwa regent kits zvakare zvakasiyana zvakare.
Mufananidzo 1
Mufananidzo1:Dhizaini inoratidza iyo kiyi matanho ezvikamu zveBiomarker panguva yeiyo nguva yakajairika yekuchinja-19 utachiona. Iyo X-axis inoratidza huwandu hwemazuva ekutapukirwa, uye iyo axis inoratidza mutoro wehutachiona, kusangana kwekutora, uye kusvinura kwemanyoji emitambo munguva dzakasiyana. Anti munhu anoreva IGM uye IGG Antibodies. Vese vr-pcr uye antigoen yekuona inoshandiswa kuona kuvapo kana kusavapo kwemuchato coronavirus, iyo ihwohwo humbowo hwakananga hwekutangisa kwekutangisa kwemurwere. Mukati mevhiki yehutachiona hwehutachiona, prcr kuwanikwa, kana kukosheswa kwekuona kunodiwa. Mushure mekutandarira kwehutachiona hwechiripo chemazuva manomwe, iyo IGM anti bove coronavirus zvishoma nezvishoma yakawedzera zvishoma muropa remurwere, asi nguva yekuvapo ipfupi, uye kurongeka kwayo kunoderera nekukurumidza. Kusiyana neizvi, Igg Anti body prus prus inoratidzika seinowanzoitika, kazhinji ingangoita mazuva 14 mushure mekutapukira hutachiona. Iyo igg yekuisa zvishoma nezvishoma inowedzera, uye inopfuurira kwenguva refu muropa. Saka, kana iyo IGM yakaonekwa muropa remurwere, zvinoreva kuti hutachiona hwave huchitapukirwa, hunova chirwere chehunyanzvi hwekutanga. Kana iyo IGG Antibody yakaonekwa muropa remurwere, zvinoreva kuti hutachiona hwehutachiona hwave kwenguva yakati. Iyo inonziwo kunonoka kutapukirwa kana kutapukirwa kwekutanga. Zvinowanzoonekwa muvarwere vari muchikamu chekupora.
Iyo biomarkers yeNovel Coronavirus
Iyo novel coronavirus is rna hutachiona, iyo inoumbwa nemapuroteni uye nucleic acids. Hutachiona hunotambira (hwevanhu) muviri, hunopinda maseru kuburikidza nekusunga saiti inoenderana, zvichikonzera immune system yekupindura uye kuburitsa zvakananga antibodies. Naizvozvo, iyo vial nuclec acids uye maAntigens, uye chaiyo masoja ekurwisa Novel coronavirus inogona kushandiswazve seyakavapo biomer Kune nucle acid yekuona, RT-PRT TUBCULGOLGOLGY INOGONESESWA, nepo nzira dzekusarudzika dzinowanzo shandiswa kuongororwa kweiyo novel coronavirus-yakatarwa antibodies. Parizvino, kune dzakasiyana siyana nzira dzekuyedza dziripo kuti dzatingasarudze kuongororwa kwehuwandu-19 hutachiona [1].
Nheyo dzakakosha dzenzira dzekuyedza bvunzo dzeNovel Coronavirus
Mazhinji idziviriro ekuongorora kweiyo Chandha Kunyangwe iyo itsva yekuyedza yekuedza ichiuya nemazita mazhinji akasiyana uye mafomu ezvino
01. Nucleic acid yekuona
Reverse Transcriptpt RT-PCR ndiyo yekutanga mhando yeyedzo yeCavid-19, inokurudzirwa nenyika yeWorld Health Organisation (Ndiani) uye nzvimbo yeUS yeChirwere Control uye Kudzivirira (CDC).
02.Rerologic Antibody Kuongororwa
Antibody ipuroteni yekudzivirira inogadzirwa mumuviri wemunhu mukupindura hutachiona. Iyo IGM ndeyemhando yekutanga yeAntibody nepo igg iri gare gare Type Antibody. Iyo serum kana plasma sampuli inowanzo kuongororwa kune kuvapo kweiyo IGM uye igg mhando dzeanti yeAntio yekuongorora kweiyo acute uye convescent zvikamu zvechivhi-19 utachiona. Aya maAnti-based Kuchenesa nzira dzinosanganisira Colidal Gondiyo Uridzo
03.Virl Antigen Kuwanikwa
Antigen chigadzirwa pahutachiona hunokwevarira nemuviri wemunhu unokonzeresa hurongwa hwekudziviririka A VIRIL Antigen iripo pahutachiona inogona kunangwa uye yaonekwa uchishandisa impunasasy. Kunge vira rna, varal maantions aripo mune yekufema turakiti revanhu vane hutachiona uye rinogona kushandiswa kuongorora chiitiko chekutapudza-chikamu chevhu. Naizvozvo, zvinowanzokurudzirwa kuunganidza mapepa ekufemera senge saliva, Nasaopharyngeal uye Orophallyngel Swabs, Bronchoalveolar Lavage Fluid (Balf) Yekutanga Antigen Kuedza.
Kusarudza nzira dzekuyedza dzenyu dzeNovel Coronavirus
Kusarudza nzira yekuyedza inosanganisira zvinhu zvakawanda, kusanganisira kiriniki mamiriro ezvinhu, kuyedza nguva yekudzora, kuyedza mari, sampling nzira dzekuunganidza, zviratidzi zvehunyanzvi zvehunyanzvi, nzvimbo uye zvishandiso zvinodiwa nemidziyo. Kuonekwa kwema acclic acids kana hutachiona hwehutachiona ndezvekupa humbowo hwakananga hwekuvapo kwehutachiona hwehutachiona uye kusimbisa kuongororwa kweutachiona hwehutachiona hwehutachiona hwehutachiona hwehutachiona. Kunyangwe paine nzira dzakawanda dzekutadza kuwanikwa, kuona kwavo kwekunzwa kweiyo novel coronavirus ndiyo yakaderera pane iyo yert-pl-pcr mopedizer. Kuongororwa kweAntti Iko kuronga kwekiriniki kwekushandiswa kwekuona kunogona kusiyana, uye nzvimbo dzekuunganidza dzaunganidzwa dzinogona kuve dzakasiyana. Kuonekwa kweiyo viral nucids acids uye fanigent inoda kuunganidzwa mutiraki yekufema uko hutachiona hwehutachiona, Sputum, kana Bronchoalveolar lavage fluid (balf). Kune antibody-yakavakirwa kubvisirwa, ropa reropa rinoda kuunganidzwa uye kuongororwa kwekuvapo kweiyo chaiyo anti-turus ant body (IGM / igg). Nekudaro, Antibody uye nucleic acid bvunzo mhinduro dzinogona kukwana. Semuenzaniso, kana muedzo wekuedza ndiro nhumbi yacho [2]
Zvakanakira uye Zvakashata zveNovel Coronavirus bvunzo
Mukuongororwa uye kurapwa protocol yeNovel coronavirus pneumonia Coronavirus kutapukirwa, nepo kuongororwa kwekutora kunoonekwawo seimwe yenzira dzekusimbisa nzira dzekuongororwa.
Pathogenic uye Setsological Zvakawanikwa
(1) Pathogenic Zvakawanikwa: Novel Coronavirus nucleic acid inogona kuwanikwa muNasophaysngeal Swabs Iyo inonyanya kuve yakarongedzwa kana fungidziro inowanikwa kubva kuderera kufema turakiti (sputum kana mhepo turakiti yekubvisa). Iwo mafungidziro anofanirwa kuendeswa kuongororwa nekukurumidza sezvinobvira mushure mekuunganidzwa.
. IGG inosvika kugumi kweinenge mana-fold kuwedzera panguva yekuvanzika kuenzaniswa nekuenzaniswa neiyo acute chikamu.
Nekudaro, kusarudzwa kwekuyedza nzira kunoenderana nenzvimbo dzenzvimbo, mirau yekurapa, nemakiriniki zvirongwa. MuUSA, iyo NIH yakapa COROVAVIRUS chirwere 2019 (COVID-19) SITE 21,10 (
Nucleic acid yekuona nzira
RT_PCR chiratidzo chakaringana nucid bvunzo yakagadzirirwa kuona kana kwete iyo novel coronavirus rna iripo mune yekufema kana imwe fungidziro. Iyo yakanaka PRR bvunzo mhedzisiro inoreva kuvapo kweNovel Coronavirus rna mune sampula kuti isimbise iyo Chand-19 utachiona. Iyo isina kunaka PCR bvunzo hazvireve kusavapo kwehutachiona hwehutachiona nekuti zvinogona kukanganiswa nemisoro yemhando yemhando kana chirwere nguva poda panhamba yakadzorerwa, nezvimwewo. Kunyangwe RT-PCR chiitiko chakajeka kwazvo, chine zvido zvakati wandei. RT-PRR bvunzo dzinogona kuve dzakasimba-zvakanyanya uye dzinoparadza nguva, zvinyoronyoro zvinoenderana nemhando yepamusoro yemuenzaniso. Izvi zvinogona kuve zvakaoma nekuti huwandu hwehutachiona hwehutachiona hurefu hwakanyanya pakati pevarwere vakasiyana asiwo vanogona kusiyana mumwoyo mapopomerwa kana sampuli yemitambo kana iyo yekutanga yezviratidzo zvechirongwa. Kuona iyo novel coronavirus inoda yakakwirira-mhando mitezo ine huwandu hwakakwana hwehuwandu hwakasimba hwehutachiona hwehutachiona.
Iyo RT-PRR bvunzo inogona kupa zvisiri izvo zvakashata mhedzisiro (nhema isina kunaka) kune vamwe varwere vane chivha-19 utachiona. Sezvatinoziva, nzvimbo huru dzekutapukirwa dzemutovhesi coronavirus iri pamapapu uye turakiti rezasi rekufema, rakadai seAlveoli naBronchi. Naizvozvo, iyo sputum fungidziro kubva pane yakadzika kukosora kana iyo bronchoalveolar lavage fluid (balf) inotariswa kuve nekunzwa kwakanyanya kwekutarisa vheji. Nekudaro, mune clinical tsika, samples inowanzo kuunganidzwa kubva kune yepamusoro yekufema turakiti nekushandisa Nasophaysngeal kana Orophallyngel Swabs. Kuunganidza izvi kufungidzira hakusi kusununguka chete kune varwere asiwo kunodawo vashandi vakadzidziswa. Kuita sampling samplive isingasviki kana nyore, mune dzimwe nguva varwere vanogona kupihwa nemuromo swab uye vabvumire kuti vatore muenzaniso kubva kuBocsal Mucosa kana rurimi ruchichizvisvetuka. Pasina zvakakwana VIRA RNA, RT-QPCR inogona kudzosa manyepo-asina kunaka bvunzo mhedzisiro. MuHubei Province, China, RT-PCR SYICTIVILE MUCHITSAUKO CHEMA CHETE CHETE CHINONZE CHINONZE 30% -50%, neavhareji ye40%. Chiyero chakanyanya chenhema-chisina kunaka chakanyanya kukonzerwa nekusimudzirwa kwakakwana.
Uye zvakare, iyo RT-PCR bvunzo inoda vashandi vakadzidziswa zvakanyanya kuti vaite zvakaoma rna yekubvisa matanho uye pcr mopper Zvinodawo huwandu hwepamusoro hwe biosfety dziviriro, nzvimbo dzinokosha dzekutengesa, uye chaiyo-nguva pcr body. MuChina, iyo RT-PCR bvunzo yeCRVid-19 Kuongororwa kunoda kuitwa muBiosfety Level 2 Laboratories Pasi pane izvi zvinodiwa, kubva pakutanga kwaJanuary kusvika pakutanga Kukadzi 2020, kugona kweChina Wuhans's CDC Laboratory yaingogona kuona mazana mashoma emakore pazuva. Kazhinji, izvi hazvingavi dambudziko kana uchiedza zvimwe zvirwere zvinotapukira. Nekudaro, kana uchibata nedenda repasi rose seyakajaira-19 pamwe nemamiriyoni evanhu kuti vaongororwe, RT-PCR inokonzerwa nenyaya yaanoda kune nzvimbo dzinokosha dzekutambisa kana zvigadzirwa zvehunyanzvi. Zvinokuvadza izvi zvinogona kudzikisira rt-pcr kuti ishandiswe sechishandiso chinoshanda pakuongorora, uye zvakare zvinogona kutungamira kunonoka mumishumo yekuyedza mhinduro.
Setsological Antibody Dection Nzira
Nekufambira mberi kwechirwere chekurwara, kunyanya mukati menguva pfupi uye kunonoka kukohwa, iyo Anti Boyer yekuona yakakwira kwazvo. Chidzidzo cheWuhan Central South South South South South South Central Zvakare, antibody ndiye chigadzirwa chekupindura kwemunhu kupopotedzana nemuchina wekusavimbika coronavirus. Iyo Anti Producest bvunzo inopa akati wandei zvakanakira rt-pcr. Chekutanga, iyo yekutsiva antibody inoedza nyore uye nekukurumidza. Antibody Literal Flow bvunzo dzinogona kushandiswa kune point-ye-yekutarisira kuendesa mhedzisiro mumaminetsi gumi nemashanu. Kechipiri, iyo chinangwa chakaonekwa neyekuongororwa kwetsiva ndiyo inorwisa munhu, iyo inozivikanwa kuve yakawanda yakagadzikana kupfuura veral rna. Munguva yekuunganidza, kutakura, kuchengetedza uye kuongororwa, iwo maitiro emiedzo yeanti Yetatu, nekuti anti printi inogoverwa zvakanyanya mukuparadzwa kweropa, pane kusarudzika kusiyanisa kusiyana kwemasangano kana uchienzaniswa nemubvunzo wekare acid. Iyo sampula vhoriyamu inodiwa kuti muedzo weanti Semuenzaniso, gumi microliter yeropa-prick ropa rakakwanira kushandiswa mune antibody lateral kuyerera bvunzo.
Kazhinji, bvunzo yemunhu anoongorora inosarudzwa sechishandiso chekuwedzera che acid acid yekuona kuti uvandudze huwandu hwekuona kweiyo novel coronavirus panguva yezvirwere zvechirwere. Kana bvunzo yeAntibody ichishandiswa pamwe neNucleic acid bvunzo, inogona kuwedzera kurongeka kweiyo kuongororwa kweCovid19 nekudzora zvingangoita manyepo uye enhema mhinduro. Iyo yazvino yekushanda inotungamira haina kukurudzira uchishandisa marudzi maviri emiedzo zvakasiyana seyakazvimirira seyakazvimirira chimiro asi inofanira kushandiswa seyakasanganiswa fomati. [2]
Mufananidzo2:Dudziro chaiyo yeNucletation AcIC acid uye Antibody Test mhinduro yekuonekwa kweNovel Coronavirus utachiona
Mufananidzo 3:Kurambidza Bio-Zvigadzirwa Co, Ltd. - Novel Coronavirus Igm / Igg Antibody Dual Philid Test Kit (yakasimba®Sars-cov-2 igm / igg antibody rapid test, latex immunochromatography)
Mufananidzo 4:Kurambidza Bio-Zvigadzirwa Co, Ltd. - Yakasimba®Novel Coronavirus (Sars-Cov-2) Multiplex chaiyo-nguva PCR Kit (kuwanikwa kwematatu majenji, fluorescent Probe nzira).
ONA:Izvi zvakanyanyisa kuterera, kugadzirira-kushandisa-shandisa pccr kt kombi inowanikwa mumhando yeLyophilized fomati (kusununguka-kuoma-kuoma maitiro) yekuchengetedza kwenguva refu. Iyo kit inogona kutakurwa uye yakachengetwa pamhepo tembiricha uye yakagadzikana kwegore rimwe. Imwe neimwe yebhuruu ine ese evagadziridza anodiwa kuti prcr amplation, kusanganisira reversecripteme, plongs, props pane prcr board yekumhanyisa kukwidziridzwa.
Mukupindura nelanavavirus kubuda, kurambidza Bio-zvigadzirwa co. Iyi kits yakakodzera kwazvo kushandiswa kwehuremu hwekuratidzira munyika uye matunhu uko kubuda kwepopi kwekuparadzwa kuri kukurumidza kupararira, uye nekupa kuongororwa uye kusimbiswa kweChidid-19 utachiona. Iyi kits ndeyeshandisirwo chete pasi pekupembera kwekukurumidzira kushandisa mvumo (peua). Kuedzwa kunogumira kumarabhoritori akasimbiswa pasi pemitemo yenyika dzenyika kana dzenharaunda.
Antigen Faction nzira
1. Viral Antigen Kuona inoiswa muboka rimwe chete rekuona zvakananga sekuonekwa kwecleic acid. Idzi nzira dzakananga dzekuona dzinotsvaga humbowo hwehutachiona hwehutachiona mune fungidziro uye inogona kushandiswa kwekuzivisa kuongororwa. Nekudaro, kusimudzira kwekunakidza kukoshwa kits kunoda kukwira kwakakwirira kweMonownal Antibodies ane hukama hwakasimba uye nekunzwa kwakasimba kugona uye kutapa hutachiona hwePathogenic. Zvinowanzotora anopfuura mwedzi mitanhatu kuti vasarudze uye optimize antioclonal antibody kuti ishandiswe mukugadzirira kweiyo antigen yekuona kititi yekukona.
2. Parizvino, iyo reagents yekuwonekwa kwakananga kweiyo novel coronavirus ichiri pasi pekutsvaga uye yekuvandudza nhanho. Naizvozvo, hapana antigence yekuona kit yakave yakasimbiswa pamwe chete uye inotengeswa. Kunyangwe zvakambotaurwa kuti dhizaini yekufungidzira muShenzhen yakagadzira chinongedzo chekunakidza kit uye clinically akaedzwa muSpain, fungidziro yekuvimbika uye kurongeka kwaisakwanisa kusimbiswa nekuda kwekuvapo kwenyaya dzemhando dzemagumo. Kusvika parizvino, nmpa (yaimbova kiina fda) haina kubvumirana chero kurwisa kititi yekuona kit yekiriniki yekushandisa parizvino. Mukupedzisa, nzira dzakasiyana siyana dzakagadzirwa dzakagadzirwa. Imwe neimwe nzira ine zvakanakira uye zvisingakwanisi. Mhedzisiro kubva kune dzakasiyana nzira dzinogona kushandiswa kuti uone kuti kuongororwa uye kukwana.
3. Kugadzira mhando yekuverenga-nguva yemhando-19 bvunzo kit ine simba zvakanyanya kubva pakuronga panguva yekutsvaga nekuvandudza. Kurambidza Bio-Chigadzirwa CO, LTD. Kits kits dzinodiwa kuti usangane nehuremu hwekugadzira uye mhando dzekutonga kuti uone kuti vanopa huwandu hwepamusoro hwekuita uye kusawirirana. Masayendisiti pakurambidza Bio-Chigadzirwa CO-Chigadzirwa CO, LTD. Iva neanopfuura makore makumi maviri
Munguva yeCovid-19 dengic, hurumende yeChinese yakatarisana nekuvhenekwa kukuru kwechiitiko chekudzivirira chirwere chehutachiona muInternational Hotspots. Musi waApril 5, pamisangano yedare reHurumende Council Convers Condish Kudzikisira uye Kuzvisimbisa Mhando Yekurapa Kwekuvaraidza Zvekutengeserana, zvakati, "Takazotarisa kuedza kwedu pazvinhu zviviri, kutanga, kukurumidza, kuti tikurumidze kunharaunda dzenyika, uye zvakare, kugadzirisa maitiro emhando, uye manejimendi ezvigadzirwa. Isu tichagadzira mupiro weChina kuti tipindurire pamwe chete nedenderedzwa repasi rose uye kuvaka nharaunda neramangwana rakagovana nevanhu.
Mufananidzo 5:Kurambidza Bio-Zvigadzirwa C., Ltd. Wovel Coronavirus Reagent yakawana iyo EU CE Kunyorera Chitupa
Chitupa Honorary
Houshensi
Mufananidzo 6. Kurambidza Bio-Zvigadzirwa C., Ltd. Yakatsigirwa Wuhan Vulcan (Houshenshan) Hondo dzechiitiko kurwisa kuhukura-19 Wuhan Vulcan Makomo muchipatara ndicho chipatara chakakurumbira muChina chinonyatsotambisa mukurapa kwekurapa kwakanyanya - 19 varwere.
Sezvo bhuku rekupedzisira coronavirus rinoenderera mberi nekuparadzira pasi rose, kugadzirwa kwakatenderedza Bio-zvigadzirwa co. Kukurumidza kuongororwa kweiyo Chand-19 utachiona chikamu chakakosha chekugadzirisa izvi kutyisidzira. Isu tinoramba tichibatsira nenzira yakakosha nekupa mapurotendi ezvekutanga mumaoko emberi mumaoko epamberi pehutano hwevashandi vehutano saka vanhu vanogona kugashira mibairo yakaoma yekuedza yavanoda. Kurambidza Bio-Zvigadzirwa C., Ltd. Kuedza kurwisa Chand-19 Chiitiko Chekuita Kuti Vapatsanidze Matipi edu, uye hunyanzvi kune dzimwe nharaunda dzenyika dzekuvakwa kwenharaunda yepasi rese.
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Kutumira Nguva: May-01-2020
